Hyperfunctioning malignant thyroid nodule in an 11-year-old girl: pathologic and molecular studies.
case_report · Level V
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Abstract
We identified a papillary carcinoma in an 11-year-old girl with a hyperfunctioning thyroid nodule. A met453thr mutation in TSHR was found in the nodule but not in normal thyroid tissue or in leukocytes. This case documents that this activating mutation is associated with neoplasia.
Medical subject headings
- Thyroid Nodule