Protein C deficiency related to valproic acid therapy: a possible association with childhood stroke.
case_report · Level V
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- Record sourced from PubMed, PMID 11060540.
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Abstract
We report a case of stroke in a child with acquired protein C deficiency receiving valproic acid (VPA). To investigate the possible association of VPA with protein C deficiency, protein C levels were measured in 20 children receiving VPA monotherapy and 20 children receiving other anticonvulsants. Protein C levels were reduced in up to 45% of the VPA-treated subjects.
Medical subject headings
- Anticonvulsants
- Protein C
- Protein C Deficiency
- Stroke
- Valproic Acid