Thalamic microglial activation in ischemic stroke detected in vivo by PET and [11C]PK1195.
case_series · Level IV
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Abstract
Using quantitative PET, the authors studied the binding of [11C]PK11195, a marker of activated microglia, in the thalamus of patients with chronic middle cerebral artery infarcts. All patients showed increased [11C]PK11195 binding in the ipsilateral thalamus, indicating the activation of microglia in degenerating projection areas remote from the primary lesion. A persistent increase in [11C]PK11195 binding suggests active, long-term thalamic microstructural changes after corticothalamic connection damage.
Medical subject headings
- Brain Ischemia
- Carbon Radioisotopes
- Isoquinolines
- Stroke
- Thalamic Nuclei