Misleading results with the 14-3-3 assay for the diagnosis of Creutzfeldt-Jakob disease.
case_series · Level IV
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- Record sourced from PubMed, PMID 11087791.
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Abstract
The definitive diagnosis of Creutzfeldt-Jakob disease (CJD) requires brain tissue analysis. A positive assay for the 14-3-3 protein in CSF has been suggested to be highly sensitive and specific in patients with CJD. The authors describe three patients for whom CSF 14-3-3 assays were falsely positive or falsely negative. Caution against overreliance on this putative biomarker is suggested in the diagnosis of CJD.
Medical subject headings
- Creutzfeldt-Jakob Syndrome
- Tyrosine 3-Monooxygenase