Artificial antigen-presenting cells as a tool to exploit the immune 'synapse'.
basic_science · Level V
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Abstract
Recent progress in molecular medicine has provided important tools to identify antigen-specific T cells. In most cases, the approach is based on oligomeric combinations of recombinant major histocompatibility complex-peptide complexes fixed to various rigid supports available for binding by the T-cell receptor. These tools have greatly increased our insight into mechanisms of immune responses mediated by CD8+ T cells. Examples of the diverse fields of application for this technology include immunization, viral infections and oral tolerance induction.
Medical subject headings
- Antigen Presentation
- CD8-Positive T-Lymphocytes
- Histocompatibility Antigens Class II
- Immunologic Techniques
- Peptides