Ventricular fibrillation: how do we stop the waves from breaking?

Weiss, J N; Chen, P S; Qu, Z; Karagueuzian, H S; Garfinkel, A · Circ Res · 2000

review · Level V

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Abstract

Combined experimental and theoretical developments have demonstrated that in addition to preexisting electrophysiological heterogeneities, cardiac electrical restitution properties contribute to breakup of reentrant wavefronts during cardiac fibrillation. Developing therapies that favorably alter electrical restitution properties have promise as a new paradigm for preventing fibrillation.

Medical subject headings