Failure of cidofovir therapy in progressive multifocal leukoencephalopathy unrelated to human immunodeficiency virus.
case_report · Level V
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Abstract
We describe the first reported human immunodeficiency virus (HIV)-seronegative patient treated with cidofovir for progressive multifocal leukoencephalopathy (PML). Marked clinical and radiological progression of PML occurred during cidofovir therapy. The improvement observed during cidofovir therapy of HIV-infected patients may be due to the effect of concomitant antiretroviral therapy rather than cidofovir.
Medical subject headings
- Anti-HIV Agents
- Cytosine
- Leukoencephalopathy, Progressive Multifocal
- Organophosphonates
- Organophosphorus Compounds