Gene expression profiles in normal and Otx2-/- early gastrulating mouse embryos.
basic_science · Level V
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- Record sourced from PubMed, PMID 11114168.
- Also identified by PMC identifier 18928.
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Abstract
The mouse Otx2 gene is a homeobox transcription factor required as early as gastrulation for the proper development of the head. We compared gene expression profiles in wild-type and Otx2(-/-) 6.5 days postcoitum embryos by using a serial analysis of gene expression assay adapted to microdissected structures. Among a broader list, the study of six genes found to be differentially expressed allows defining a role for Otx2 in the orchestration of cell movements leading to the adequate organization of the embryo before gastrulation.
Medical subject headings
- Gastrula
- Gene Expression Profiling
- Head
- Homeodomain Proteins
- Nerve Tissue Proteins
- Trans-Activators