Myositis associated graft-versus-host-disease presenting as respiratory muscle weakness.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 11120911.
- Also identified by PMC identifier 1745896.
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Abstract
Myositis associated with graft-versus-host-disease (GVHD) typically presents with proximal muscle weakness, myalgias, and a raised creatinine phosphokinase (CPK) level. We report a case of a 51 year old man who developed respiratory muscle weakness five years after an allogeneic bone marrow transplant for multiple myeloma. His symptoms included tachypnoea, abdominal paradox, and orthopnoea. Pulmonary function tests revealed diminished vital capacity and maximal inspiratory and expiratory pressures. Serum CPK levels were raised and a peripheral muscle biopsy specimen was consistent with GVHD. He improved with immunosuppressive therapy.
Medical subject headings
- Bone Marrow Transplantation
- Graft vs Host Disease
- Myositis
- Respiratory Muscles