Random genetic drift determines the level of mutant mtDNA in human primary oocytes.
basic_science · Level V
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- Record sourced from PubMed, PMID 11133360.
- Also identified by PMC identifier 1235288.
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Abstract
We measured the proportion of mutant mtDNA (mutation load) in 82 primary oocytes from a woman who harbored the A3243G mtDNA mutation. The frequency distribution of mutation load indicates that random drift is the principal mechanism that determines the level of mutant mtDNA within individual oocytes.
Medical subject headings
- DNA, Mitochondrial
- Gene Frequency
- Oocytes
- Point Mutation