Successful treatment of hypothalamic seizures and precocious puberty with GnRH analogue.
case_series · Level IV
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Abstract
Patients with hypothalamic hamartomas and precocious puberty may develop gelastic seizures that are resistant to conventional antiepileptic drug therapies. While treating precocious puberty in two such patients with long-acting GnRH analogue, the authors observed cessation of gelastic seizures. Although the mechanism is unclear, long-acting GnRH analogue should be considered as a possible therapy for gelastic seizures in patients with hypothalamic hamartomas.
Medical subject headings
- Brain Diseases
- Gonadotropin-Releasing Hormone
- Hamartoma
- Puberty, Precocious