Is tissue plasminogen activator a threat to neurons?
editorial · Level V
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- Record sourced from PubMed, PMID 11135603.
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Abstract
The clot-busting drug tissue plasminogen activator (tPA) is currently the only FDA-approved therapy for acute stroke. However, increasing evidence suggests that tPA can also contribute to excitotoxic neuronal damage in animal models of stroke.
Medical subject headings
- Neurons
- Stroke
- Tissue Plasminogen Activator