Gamma-hydroxybutyrate overdose and physostigmine: teaching new tricks to an old drug?
case_series · Level IV
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- Record sourced from PubMed, PMID 11145779.
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Abstract
Gamma-hydroxybutyrate was introduced as an anesthetic agent in the 1960s and is still used in some countries, despite recognized disadvantages. More recently, it has emerged as a popular recreational drug. We report 3 cases of gamma-hydroxybutyrate overdose, the effects of which were reversed by the administration of low-dose intravenous physostigmine. The origins of this regimen and the case for physostigmine as a potential antidote are described.
Medical subject headings
- Antidotes
- Cholinesterase Inhibitors
- Physostigmine
- Sodium Oxybate