Clinical and spectroscopic improvement in HIV-associated cognitive impairment.
prospective_cohort · Level II
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Abstract
To assess the impact of highly active antiretroviral therapy (HAART) on AIDS-associated cognitive impairment, 22 patients with AIDS with (n = 11) and without (n = 11) cognitive deficit were evaluated clinically and by MRS every 3 months for 9 months. Nineteen patients were on HAART at study entry, 21 after 2 months. Cognitively impaired patients presented with a subcorticofrontal deficit and decreased N-acetyl-aspartate in frontal white matter. These clinical and metabolic abnormalities reversed partially on HAART, whereas they remained within normal limits in cognitively unimpaired patients.
Medical subject headings
- AIDS Dementia Complex
- Antiretroviral Therapy, Highly Active
- Magnetic Resonance Spectroscopy