Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 11148253.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The expression levels of three synaptic proteins (synaptophysin, synaptotagmin, and growth-associated protein 43 [GAP43]) in AD cases clinically classified by Clinical Dementia Rating (CDR) score were analyzed. Compared with control subjects (CDR = 0), mild (early) AD (CDR = 0.5 to 1) cases had a 25% loss of synaptophysin immunoreactivity. Levels of synaptotagmin and GAP43 were unchanged in mild AD, but cases with CDR of >1 had a progressive decrement in these synaptic proteins. Thus, synaptic injury in frontal cortex is an early event in AD.
Medical subject headings
- Alzheimer Disease
- Calcium-Binding Proteins
- Membrane Glycoproteins
- Nerve Tissue Proteins
- Synapses