Relaxation induced by omeprazole does not change in diabetic rabbit corpus cavernosum.

Abstract

To investigate the changes in relaxation responses to omeprazole in corpus cavernosal strips from rabbits with diabetes induced by alloxan. Diabetes was induced in 10 New Zealand white rabbits. After 8 weeks, the reactivity to electrical-field stimulation, carbachol and omeprazole of corporal strips from the penises of the diabetic animals and from 10 untreated controls was assessed in organ chambers. In the diabetic group, the relaxation responses of corpus cavernosal strips to omeprazole were comparable with those of the control group, whereas the relaxation responses to electrical field stimulation and carbachol were impaired. The relaxant effect of omeprazole in corpus cavernosum was not affected by diabetes, in which neurogenic and endothelium-mediated relaxations were impaired.