Limitations of chromosome classification by multicolor karyotyping.
case_series · Level IV
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- Record sourced from PubMed, PMID 11222105.
- Also identified by PMC identifier 1275623.
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Abstract
Multicolor karyotyping technologies, such as spectral karyotyping (SKY) (Schröck et al.1996; Liyanage et al. 1996) and multiplex (M-) FISH (Speicher et al. 1996), have proved to be extremely useful in prenatal, postnatal, and cancer cytogenetics. However, these technologies have inherent limitations that, in certain situations, may result in chromosomal misclassification. In this report, we present nine cases, which fall into five categories, in which multicolor karyotyping has produced erroneous interpretations. Most errors appear to have a similar mechanistic basis.
Medical subject headings
- Chromosome Aberrations
- Chromosome Painting