Linkage analysis of a complex pedigree with severe bipolar disorder, using a Markov chain Monte Carlo method.
other · Level V
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- Record sourced from PubMed, PMID 11222106.
- Also identified by PMC identifier 1275626.
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Abstract
Recently developed algorithms permit nonparametric linkage analysis of large, complex pedigrees with multiple inbreeding loops. We have used one such algorithm, implemented in the package SimWalk2, to reanalyze previously published genome-screen data from a Costa Rican kindred segregating for severe bipolar disorder. Our results are consistent with previous linkage findings on chromosome 18 and suggest a new locus on chromosome 5 that was not identified using traditional linkage analysis.
Medical subject headings
- Bipolar Disorder
- Chromosome Mapping
- Markov Chains
- Monte Carlo Method