Pro-Frame: similarity-based gene recognition in eukaryotic DNA sequences with errors.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 11222258.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Performance of existing algorithms for similarity-based gene recognition in eukaryotes drops when the genomic DNA has been sequenced with errors. A modification of the spliced alignment algorithm allows for gene recognition in sequences with errors, in particular frameshifts. It tolerates up to 5% of sequencing errors without considerable drop of prediction reliability when a sufficiently close homologous protein is available (normalized evolutionary distance similarity score 50% or higher).
Medical subject headings
- Algorithms
- Sequence Alignment
- Sequence Analysis, DNA