Antibodies to brain antigens following stroke.
prospective_cohort · Level II
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- Record sourced from PubMed, PMID 11222800.
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Abstract
Cerebral necrosis following stroke exposes brain antigens to the immune system, potentially initiating an antibody response. The authors measured levels of antibodies to specific neuronal antigens, neurofilaments (NF), and a ubiquitous antigen, cardiolipin (CL), in 45 patients following an acute first-ever stroke, within 48 hours, and 1, 3, and 6 months later. The mean levels of anti-NF antibodies were elevated compared with baseline at 1, 3, and 6, months (p = 0.012, 0.002, and 0.003 by paired t-test). Anti-CL levels did not change significantly.
Medical subject headings
- Antibodies
- Brain
- Cardiolipins
- Neurofilament Proteins
- Stroke