Isolated diffuse mesangial sclerosis and Wilms tumor suppressor gene.
case_series · Level IV
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- Record sourced from PubMed, PMID 11241056.
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Abstract
Diffuse mesangial sclerosis is a rare renal disease, occurring either in isolation or as part of Denys-Drash syndrome. Denys-Drash syndrome originates from mutations of the Wilms tumor suppressor gene (WT1 ). We describe the presence of WT1 mutations in 7 Japanese children with isolated diffuse mesangial sclerosis.
Medical subject headings
- Genes, Wilms Tumor
- Glomerular Mesangium
- Kidney Diseases
- Point Mutation