Paraneoplastic and metastatic neurologic complications of Merkel cell carcinoma.
case_report · Level V
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Abstract
Merkel cell carcinoma is a rare primary cutaneous neuroendocrine tumor that is locally aggressive and frequently accompanied by distant metastases. Neurologic complications of Merkel cell carcinoma are rare. We describe a 69-year-old man who presented with Lambert-Eaton myasthenic syndrome and was found to have Merkel cell carcinoma. The paraneoplastic syndrome improved with initial treatment of the malignancy. He subsequently developed a solitary brain metastasis and died of leptomeningeal carcinomatosis.
Medical subject headings
- Carcinoma, Merkel Cell
- Lambert-Eaton Myasthenic Syndrome
- Paraneoplastic Syndromes
- Skin Neoplasms