Type I collagen degradation does not diminish with RA disease duration.
cross_sectional · Level IV
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- Record sourced from PubMed, PMID 11247878.
- Also identified by PMC identifier 1753623.
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Abstract
To assess the relation between type I collagen degradation and the duration of rheumatoid arthritis (RA). The serum concentrations of cross linked carboxyterminal telopeptide of type I collagen (ICTP) measured earlier in a community based series (90 patients) and a hospital based series (59 patients) were re-evaluated with reference to the duration of RA. The serum ICTP showed a positive correlation with the duration of the disease in the hospital based series (r(s)=0.40, p<0.01) but not in the community based one (r(s)=0.18, p=0.10). Type I collagen degradation predominantly reflecting pathological bone destruction does not seem to diminish in longlasting RA.
Medical subject headings
- Arthritis, Rheumatoid
- Collagen