A familial risk profile for osteoporosis.
case_control · Level III
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Abstract
To describe genetic epidemiologic aspects of osteoporosis. 69 patients with osteoporosis were interviewed regarding personal and family histories of osteoporosis and related fractures. Family history information was obtained on 421 first degree and 748 second degree relatives. 45% of cases reported a family history of osteoporosis. Familial cases were characterized neither by an earlier age of diagnosis nor by a greater degree of phenotypic severity. Empiric risks for osteoporosis were highest for mothers, 33%, and were 19% for sisters. These results provide an initial genetic epidemiologic profile for osteoporosis and information useful for genetic counseling.
Medical subject headings
- Osteoporosis