Recurrence risks to sibs of MS index cases: impact of consanguineous matings.
retrospective_cohort · Level III
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Abstract
Using population-based data, the authors identified 24 MS index cases whose parents were related. Twenty-two had 67 sibs of whom 6 also had MS, yielding a recurrence risk of approximately 9%, significantly higher than for sibs of MS index cases from nonconsanguineous parents. These findings support the concept that multiple interacting genes increase the risk of MS.
Medical subject headings
- Consanguinity
- Multiple Sclerosis