A feedback-controlled ensemble model of the stress-responsive hypothalamo-pituitary-adrenal axis.
basic_science · Level V
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- Record sourced from PubMed, PMID 11274427.
- Also identified by PMC identifier 31173.
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Abstract
The present work develops and implements a biomathematical statement of how reciprocal connectivity drives stress-adaptive homeostasis in the corticotropic (hypothalamo-pituitary-adrenal) axis. In initial analyses with this interactive construct, we test six specific a priori hypotheses of mechanisms linking circadian (24-h) rhythmicity to pulsatile secretory output. This formulation offers a dynamic framework for later statistical estimation of unobserved in vivo neurohormone secretion and within-axis, dose-responsive interfaces in health and disease. Explication of the core dynamics of the stress-responsive corticotropic axis based on secure physiological precepts should help to unveil new biomedical hypotheses of stressor-specific system failure.
Medical subject headings
- Feedback
- Hypothalamo-Hypophyseal System
- Pituitary-Adrenal System
- Stress, Physiological