Aberrant expression of HDMX proteins in tumor cells correlates with wild-type p53.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 11280734.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
It has been shown that the Hdmx gene is amplified in a subset of gliomas, but thus far, no data are available on HDMX protein expression in tumor cells. We now report that a significant fraction of tumor cell lines expresses increased HDMX levels compared with normal cells; in general, HDMX expression in these tumor cell lines correlates with the presence of wild-type p53. Analysis of tumor material showed that high HDMX expression is not a result of cell line establishment. Interestingly, several cell lines express alternative, shorter HDMX proteins. These results suggest that deregulated expression of HDMX plays a role in carcinogenesis as an alternative way to inactivate p53.
Medical subject headings
- Neoplasm Proteins
- Nuclear Proteins
- Proto-Oncogene Proteins
- Tumor Suppressor Protein p53