Unrelated umbilical cord stem cell transplantation for X-linked immunodeficiencies.
case_report · Level V
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- Record sourced from PubMed, PMID 11295723.
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Abstract
Banked unrelated umbilical cord blood matched at 5 of 6 human leukocyte antigen loci was used to reconstitute the immune system in 2 brothers with X-linked lymphoproliferative syndrome and 1 boy with X-linked hyperimmunoglobulin-M syndrome. Pretransplant cytoreduction and posttransplant graft-versus-host prophylaxis were given. Hematopoietic engraftment and correction of the genetic defects were documented by molecular techniques. Two years after transplantation, all 3 patients have normal immune systems. These reports support the wider use of banked partially matched cord blood for transplantation in primary immunodeficiencies.
Medical subject headings
- Fetal Blood
- Hematopoietic Stem Cell Transplantation
- Lymphoproliferative Disorders