Vitamin D and bone mineral density in ambulatory women living in Buenos Aires, Argentina.

Abstract

The aim of this study was to determine possible associations between bone mineral density (BMD), 25-hydroxyvitamin D (25(OH)D) and intact parathyroid hormone (PTH). In a retrospective study we examined the case notes of free-living postmenopausal women living in our city (34 degrees S). We also report a low prevalence of vitamin D deficiency (25(OH)D < 25 nmol/1, 5.6%) and of secondary hyperparathyroidism (intact PTH > 65 pg/ml, 7.5%). Age was correlated with BMD at the lumbar spine (r = -0.25, p = 0.00038) and femoral neck (r = -0.252, p = 0.0003). Body mass index (BMI) was correlated with BMD at the femoral neck (r = 0.177, p = 0.021) but not at the lumbar spine. 25(OH)D was positively correlated with BMD at the femoral neck (r = 0.149, p = 0.036) but not at the lumbar spine. PTH was positively correlated with age (r = 0.279, p = 0.012) and negatively correlated with 25(OH)D (r = -0.322, p = 0.0036). PTH was also negatively correlated with BMD at the lumbar spine (r = -0.258, p = 0.02) and the femoral neck (r = -0.282, p = 0.011). Forward stepwise multiple regression showed that BMI, age and 25(OH)D made significant contributions to BMD at the femoral neck. PTH also showed a significant contribution to BMD at both sites. In conclusion, weak correlations found between PTH and 25(OH)D and BMD suggest these biochemical variables, among other factors, contribute to lumbar spine and femoral neck BMD.