Bronchoconstriction following nebulised colistin in cystic fibrosis.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 11316693.
- Also identified by PMC identifier 1718770.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Nebulised colistin is regularly used as antipseudomonal therapy in children with cystic fibrosis. We assessed bronchoconstriction in response to nebulised colistin in 58 children. Nebulised colistin significantly reduced FEV(1), MEF(25%), and SaO(2) for 15 minutes. In 20 children the reduction was greater than 10% from baseline FEV(1), and was still at that level in five at 30 minutes. Subjective assessment, baseline FEV(1), and serum IgE were unable to identify susceptible children. It is recommended that children receiving colistin should be carefully assessed for bronchoconstriction.
Medical subject headings
- Anti-Bacterial Agents
- Bronchoconstriction
- Colistin
- Cystic Fibrosis