Pregnancy with cytochrome oxidase-deficient mitochondrial myopathy.

Soccio, P S; Phillips, W P; Bonisteel, P; Bennett, K A · Obstet Gynecol · 2001

case_report · Level V

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Abstract

Cytochrome oxidase-deficient mitochondrial myopathies represent a heterogeneous group of muscle disorders. Physical stress can cause life-threatening risks related to rhabdomyolysis or respiratory compromise. A 21-year-old primigravida with cytochrome C oxidase-deficient mitochondrial myopathy who presented for obstetric care at 8 weeks' gestation complained of muscle fatigue and spasm after exertion. The increased metabolic demands of pregnancy led to worsening pain, muscle fatigue, and ultimately complete immobility. Cytochrome oxidase-deficient mitochondrial myopathies are rare but serious complications of pregnancy.

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