Increased familial risk of cluster headache.

Leone, M; Russell, M B; Rigamonti, A; Attanasio, A; Grazzi, L; D'Amico, D; Usai, S; Bussone, G · Neurology · 2001

retrospective_cohort · Level III

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Abstract

The authors studied the occurrence of cluster headache in the families of 220 Italian patients with cluster headache. A positive family history was found in 20% (44/220) of the families. Compared with the general population, first-degree relatives had a 39-fold significantly increased risk of cluster headache. Second-degree relatives had an eightfold significantly increased risk. The increased familial risk strongly supports the hypothesis that cluster headache has a genetic component in some families.

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