Parkinson's disease is not associated with the combined alpha-synuclein/apolipoprotein E susceptibility genotype.
case_control · Level III
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- Record sourced from PubMed, PMID 11357958.
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Abstract
A recent study showed significant association of sporadic Parkinson's disease with a polymorphism within the alpha-synuclein gene and closely linked DNA markers on chromosome 4q and the APOE epsilon4 allele. A combined alpha-synuclein/APOE-epsilon4 genotype increased the relative risk of developing Parkinson's disease 12-fold. We failed to confirm this association in a much larger sample of histopathologically proven cases of Parkinson's disease and controls.
Medical subject headings
- Apolipoproteins E
- Nerve Tissue Proteins
- Parkinson Disease