Effect of corticosteroids on nuclear factor-kappaB activation and hemodynamics in late septic shock.

Abstract

To describe the underlying pathophysiologic mechanisms of the effect of corticosteroids in a patient with late septic shock. Case report. The medical intensive care unit at University Medical Center Utrecht. An 86-yr-old female patient with late septic shock requiring mechanical ventilation and vasopressive agents. Administration of hydrocortisone, 300 mg daily. Within 3 days of corticosteroid treatment, the patient could be weaned of vasopressive agents and mechanical ventilation. Serum C-reactive protein levels normalized. Nuclear factor-kappaB activation in unstimulated and in vitro lipopolysaccharide-stimulated peripheral blood mononuclear cells decreased to background level within 5 days. Repeated functional tests of the hypothalamic-pituitary-adrenal axis were normal. Our data suggest that the pathophysiologic mechanism behind the clinical effects of supraphysiologic doses of corticosteroids in late septic shock is directly related to the inhibition of nuclear factor-kappaB in peripheral blood mononuclear cells.