The allogeneic response and tumor immunity.
review · Level V
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- Record sourced from PubMed, PMID 11385492.
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Abstract
The strong allogeneic response to donor MHC molecules in transplantation and the weak response to tumor antigens represent two important and divergent but potentially interactive immune responses. A patient's response to allogeneic MHC molecules might promote an effective T-cell response to self MHC-restricted tumor peptides and the possibilities for this are discussed here. These allogeneic responses might successfully be harnessed to promote the immune eradication of metastatic cancer.
Medical subject headings
- Immunotherapy
- Isoantigens
- Major Histocompatibility Complex
- Neoplasms
- T-Lymphocytes