Current efficacy of postexposure prophylaxis against measles with immunoglobulin.

Endo, A; Izumi, H; Miyashita, M; Taniguchi, K; Okubo, O; Harada, K · J Pediatr · 2001

other · Level V

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Abstract

We assessed results after postexposure prophylaxis against measles with immunoglobulin administered intramuscularly. Children were given 0.33 mL/kg of immunoglobulin from commercially available lots containing various titers of measles antibody within 5 days after exposure. In children receiving immunoglobulin with a titer of < or =16 IU/mL, 57% had clinically evident measles. Immunoglobulin preparations with higher measles antibody titers are required.

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