Hepatic hemangioendothelioma associated with production of humoral thyrotropin-like factor.

Ayling, R M; Davenport, M; Hadzic, N; Metcalfe, R; Buchanan, C R; Howard, E R; Mieli-Vergani, G · J Pediatr · 2001

case_report · Level V

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Abstract

We report on 7 patients referred for treatment of hepatic hemangioendothelioma with increased thyrotropin levels. The serum thyroxine level was decreased in 4 and increased in 2. Immunohistochemistry showed positive staining of tumor, but not of normal liver tissue, for thyrotropin. We propose secretion by the tumor of a thyrotropin-like factor.

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