Acute tubulointerstitial nephritis associated with the selective COX-2 enzyme inhibitor, rofecoxib.
case_report · Level V
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Abstract
The nephrotoxic effect of COX-2 selective inhibitors has not yet been established. We report a case of reversible acute renal failure due to acute tubulointerstitial nephritis, confirmed by histology of a renal biopsy sample, associated with taking rofecoxib, a selective cyclo-oxygenase-2 (COX-2) inhibitor.