Association study of dopamine D2, D3 receptor gene polymorphisms with motor fluctuations in PD.
case_control · Level III
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- Record sourced from PubMed, PMID 11425949.
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Abstract
The authors investigated the association between dopamine receptor D2, D3 gene polymorphisms, and the risk of developing motor fluctuations in PD. DRD3 BalI and MspI polymorphisms were not associated with risk of developing motor fluctuations. However, the genotypic distribution of DRD2 TaqIA polymorphism was significantly different in motor fluctuators and nonmotor fluctuators. These findings suggest that DRD2 TaqIA polymorphism may be associated with an increased risk for developing motor fluctuations in PD.
Medical subject headings
- Parkinson Disease
- Polymorphism, Genetic
- Receptors, Dopamine D2