Intention tremor, parkinsonism, and generalized brain atrophy in male carriers of fragile X.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 11445641.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The authors report five elderly men with the fragile X premutation who had a progressive action tremor associated with executive function deficits and generalized brain atrophy. These individuals had elevated fragile X mental retardation 1 gene (FMR1) messenger RNA and normal or borderline levels of FMR1 protein. The authors propose that elevations of FMR1 messenger RNA may be causative for a neurodegenerative syndrome in a subgroup of elderly men with the FMR1 premutation.
Medical subject headings
- Brain Diseases
- Fragile X Syndrome
- Heterozygote
- Motivation
- Parkinsonian Disorders
- RNA-Binding Proteins
- Tremor