Gastric antral vascular ectasia in systemic sclerosis: complete resolution with methylprednisolone and cyclophosphamide.
case_report · Level V
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- Record sourced from PubMed, PMID 11454645.
- Also identified by PMC identifier 1753805.
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Abstract
A case of severe, transfusion dependent anaemia in a 72 year old woman, which on endoscopy was found to be due to gastric antral vascular ectasia (GAVE), is reported. Repeated endoscopic sclerotherapy was ineffective. She subsequently developed Raynaud's phenomenon and on further investigation was found to have classical systemic sclerosis with lung involvement. Treatment with pulses of intravenous methylprednisolone and cyclophosphamide resulted in significant improvement in her pulmonary function tests and skin score. Coincidentally, her haemoglobin stabilised and further endoscopic examinations were normal. This is the first report of cyclophosphamide and methylprednisolone leading to complete and sustained resolution of GAVE in association with systemic sclerosis.
Medical subject headings
- Anti-Inflammatory Agents
- Cyclophosphamide
- Gastric Antral Vascular Ectasia
- Immunosuppressive Agents
- Methylprednisolone
- Scleroderma, Systemic