Large-scale production of mouse phenotypes: the search for animal models for inherited diseases in humans.
basic_science · Level V
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Abstract
This paper is aimed principally at bioinformaticians and biologists as an introduction to recent advances in mouse mutagenesis, concentrating on genome-wide screens utilising the powerful mutagen N-ethyl-N-nitroso-urea (ENU). It contains a brief background to the underlying genetics as well as details of the practical aspects of organisation and data capture for such projects.
Medical subject headings
- Computational Biology
- Mice