Is carbamazepine teratogenic? A prospective controlled study of 210 pregnancies.
prospective_cohort · Level II
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Abstract
The Israeli Teratogen Information Service prospectively followed up 210 pregnancies with first trimester carbamazepine exposure. Pregnancy outcome was compared with that of two overlapping controls, matched and general (n = 629), exposed to nonteratogenic agents. Our study suggests a twofold increase in the rate of major congenital anomalies (12/160 [carbamazepine] versus 18/560 [general control]; relative risk 2.24; 95% CI 1.1-4.56) and a birth weight reduction of approximately 250 g after in utero exposure to carbamazepine.
Medical subject headings
- Abnormalities, Drug-Induced
- Anticonvulsants
- Carbamazepine
- Epilepsy