Autoimmune disease: why and where it occurs.

Marrack, P; Kappler, J; Kotzin, B L · Nat Med · 2001

review · Level V

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Abstract

Autoimmune disease is controlled by genetic and environmental factors. Both of these affect susceptibility to autoimmunity at three levels: the overall reactivity of the immune system, the specific antigen and its presentation, and the target issue.

Medical subject headings