Influence of maternal and fetal glucokinase mutations in gestational diabetes.
case_report · Level V
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- Record sourced from PubMed, PMID 11483936.
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Abstract
We report 2 insulin-treated pregnancies in a mother with hyperglycemia resulting from a glucokinase gene mutation. The inheritance of a glucokinase mutation in 1 child reduced his intrauterine growth (birth weight less than first percentile) by reducing fetal insulin secretion. We discuss the implications for obstetric management of patients with glucokinase mutations.
Medical subject headings
- Diabetes, Gestational
- Fetus
- Glucokinase
- Mutation