Kinin-mediated anaphylactoid reaction implicated in acute intra-operative pulseless electrical activity.
case_report · Level V
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Abstract
A 65-year-old patient undergoing total hip replacement under general anaesthesia suffered acute pulseless electrical activity with a fatal outcome. A kinin-mediated analphylactoid reaction following administration of a polygeline plasma expander (Haemaccel) was implicated by in vitro testing. This case report illustrates the diagnostic difficulties posed by non-histaminoid anaphylactoid reactions and the resistance to epinephrine of kinin-mediated hypotension.
Medical subject headings
- Anaphylaxis
- Death, Sudden, Cardiac
- Kinins
- Plasma Substitutes
- Polygeline