A pharmacokinetic model for factor VIII dosing during active haemorrhage in patients with haemophilia A.
basic_science · Level V
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Abstract
A theoretical one-compartment pharmacokinetic model is described, the aim of which is to guide factor VIII replacement therapy in patients with haemophilia A suffering from significant and ongoing haemorrhage. Based on our calculations, plasma factor VIII concentrations can decrease at a rapid rate even with non-severe blood loss.
Medical subject headings
- Factor VIII
- Hemophilia A
- Hemorrhage
- Models, Biological