FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis.
basic_science · Level V
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- Record sourced from PubMed, PMID 11504921.
- Also identified by PMC identifier 56968.
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Abstract
The FEZ1/LZTS1 gene maps to chromosome 8p22, a region that is frequently deleted in human tumors. Alterations in FEZ1/LZTS1 expression have been observed in esophageal, breast, and prostate cancers. Here, we show that introduction of FEZ1/LZTS1 into Fez1/Lzts1-negative cancer cells results in suppression of tumorigenicity and reduced cell growth with accumulation of cells at late S-G(2)/M stage of the cell cycle. Fez1/Lzts1 protein is hyperphosphorylated by cAMP-dependent kinase during cell-cycle progression. We found that Fez1/Lzts1 is associated with microtubule components and interacts with p34(cdc2) at late S-G(2)/M stage in vivo. Present data show that FEZ1/LZTS1 inhibits cancer cell growth through regulation of mitosis, and that its alterations result in abnormal cell growth.
Medical subject headings
- Chromosomes, Human, Pair 8
- DNA-Binding Proteins
- Genes, Tumor Suppressor
- Neoplasms
- Tumor Suppressor Proteins