Arthus reaction to recombinant hepatitis B virus vaccine.

Froehlich, H; Verma, R · Clin Infect Dis · 2001

case_report · Level V

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Abstract

A severe, local, inflammatory, late-phase reaction accompanied by skin necrosis occurred after an infant was given an intramuscular injection of recombinant hepatitis B virus vaccine. The clinical course and appearance of the rash were typical of an Arthus reaction. Although not identical to this case, prior reported cases of complement-mediated reactions occurring after hepatitis B virus infection or vaccination provide theoretical support for this diagnosis.

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