Polymeric microspheres composed of pH/temperature-sensitive polymer complex.
basic_science · Level V
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- Record sourced from PubMed, PMID 11516081.
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Abstract
A new pH/temperature-sensitive polymer system with transitions resulting both from polymer-water and polymer-polymer interactions has been demonstrated using the mixture of poly(N,N-dimethylamino)ethyl methacrylate (DMAEMA) and polyethyl acrylamide (EAAm). Based on the pH/temperature sensitivity of polymer mixture, the microsphere for pH/temperature-sensitive drug release have been designed and characterized. Hydrocortisone was used as a model drug. This gave the control of hydrocortisone release in an on-off manner without considerable lag time.
Medical subject headings
- Biocompatible Materials
- Drug Delivery Systems
- Polymers